铅对人体的毒害早已被肯定,而铅致人体染色体畸变有所报道,但报道不多。我们与同济医大基础医学部协作对32例铅作出(蓄电池工人)和20例对照组(未接触铅的健康人),进行了外周血淋巴细胞染色体畸变的研究。接触组人员均选择无嗜烟酒癖,近期未服用任何可疑诱变的药物;未接触可能诱变的苯、苯胺、砷等化学物质和放射线、微波辐射等物理刺激。对照组无铅及其他职业危害接触史,健康情况良好,其他条件同接触组对两组人外周血淋巴细胞进行培养,制成可供染色体畸变分析用的标本,对每例分析100个细胞,每一细胞中的染色体进行计数,观察染色单体型或染色体型的损伤,如对染色单体型畸变的裂隙、等位染色单体裂隙、单体断裂等及染色体型的畸变如 Lead poisoning to the human body has long been affirmed, and lead to human chromosomal aberrations have been reported, but few reports. We collaborated with Tongji Medical University Department of Basic Medicine in 32 cases of lead made (battery workers) and 20 cases of control group (lead-free healthy people), the peripheral blood lymphocyte chromosome aberrations were studied. People in the contact group all chose non-addicted alcohol addicts and did not take any suspicious mutagenic drugs recently. They did not get any chemical stimuli such as benzene, aniline and arsenic, and other physical stimuli such as radiation and microwave radiation. Control group of lead and other occupational hazards exposure history, good health, other conditions with the contact group of two groups of human peripheral blood lymphocytes were cultured for chromosomal aberration analysis specimens were prepared for each case analysis of 100 cells, The number of chromosomes in each cell is counted to observe chromatid or chromosome-typed lesions such as chromatid chromosomes, cleavages, monomer breaks, and chromosomal aberrations such as