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本实验根据Border方法复制膜性肾小球肾炎模型。实验发现:实验性膜性肾小球肾炎的血浆和肾组织的脂质过氧化物(LPO)浓度显著升高,而全血和肾组织的超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活性明显降低,提示实验性膜性肾小球肾炎存在由活性氧所致的肾组织脂质过氧化损伤,其抗氧化能力降低。用川芎嗪进行治疗,减轻蛋白尿,改善肾功能,提高肾组织和血中SOD和GSH-Px活性,降低脂质过氧化物的含量,从而改善肾脏病变的程度。
This experiment replicated the membranous glomerulonephritis model according to the Border method. It was found that lipid peroxide (LPO) concentrations in the plasma and kidney tissues of experimental membrane glomerulonephritis were significantly elevated, while superoxide dismutase (SOD) and glutathione in whole blood and kidney tissues. The activity of peroxidase (GSH-Px) was significantly reduced, suggesting that there was lipid peroxidation damage in the renal tissue induced by reactive oxygen species in experimental membrane glomerulonephritis, and its antioxidant capacity was reduced. Treatment with tetramethylpyrazine reduced proteinuria, improved renal function, increased activity of SOD and GSH-Px in renal tissue and blood, and decreased lipid peroxide content, thereby improving the degree of renal disease.