By using a non-perturbative quark propagator with the lowest-dimensional condensate contributions from the QCD vacuum, the non-perturbative effect to K-factor of the Drell-Yan process is numerically investigated for 12 6 C12 6C collision at the center-of-mass energy √s = 200 GeV, 630 GeV respectively. Calculated results show that the non-perturbative QCD effect has just a weak influence on K-factor in the two cases.