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目的:探讨卵巢早衰(POF)、卵巢功能低下、染色体异常、反复胚胎种植失败患者在辅助生殖助孕过程中行供卵冻融胚胎移植(FET)的临床疗效。方法:在本院行供卵FET的91个周期为研究组,选择同期常规FET的1 278个周期为对照组,对其妊娠结局进行比较。结果:研究组患者平均移植胚胎数、种植率低于对照组,其中平均移植胚胎数差异有统计学意义(P<0.05);但研究组患者临床妊娠率略高于对照组,且研究组各年龄段的临床妊娠率均略高于对照组,其中≤30岁研究组患者临床妊娠率与对照组相比较,差异有统计学意义(P<0.05)。研究组各年龄组间胚胎种植率、临床妊娠率、流产率、异位妊娠率以及抱婴回家率均无统计学差异;对照组随年龄的增加胚胎种植率、临床妊娠率以及抱婴回家率呈下降趋势,且各年龄组间差异有统计学意义(P<0.05)。研究组中自然周期移植与人工周期相比较,平均移植胚胎数、胚胎种植率、临床妊娠率、流产率、异位妊娠率以及抱婴回家率之间差异均无统计学意义(P>0.05)。结论:供卵FET是治疗POF、遗传性疾病等不能生育健康子代妇女的有效方法;自然周期、激素替代周期均可使种植率和妊娠率达到同样良好的结局。
OBJECTIVE: To investigate the clinical efficacy of premature ovarian failure (POF), ovarian dysfunction, chromosomal abnormalities and repeated embryo implantation failure during assisted reproductive pregnancy assisted by frozen-thawed embryo transfer (FET). Methods: A total of 91 cycles of ovulation FET in our hospital were selected as the study group. A total of 1 278 cycles of conventional FET were selected as the control group, and their pregnancy outcomes were compared. Results: The average number of transplanted embryos and implantation rate in the study group was lower than that in the control group, and the average number of transplanted embryos was statistically significant (P <0.05). However, the clinical pregnancy rate in the study group was slightly higher than that in the control group The clinical pregnancy rate in the age group was slightly higher than that in the control group, and the clinical pregnancy rate in the study group ≤30 years was significantly different from that in the control group (P <0.05). There was no significant difference in embryo implantation rate, clinical pregnancy rate, miscarriage rate, ectopic pregnancy rate and rate of returning to cotains between study groups in all age groups. Embryo implantation rate, clinical pregnancy rate, Family rate showed a downward trend, and the difference between the age groups was statistically significant (P <0.05). There was no significant difference in the average number of transplanted embryos, embryo implantation rate, clinical pregnancy rate, miscarriage rate, ectopic pregnancy rate and the rate of returning to the baby compared with the artificial cycle in the study group ). Conclusion: Ovulation FET is an effective method to treat POF, hereditary diseases and other offspring that can not give birth to healthy offspring. Both natural cycles and hormone replacement cycles can achieve the same good results in implantation rate and pregnancy rate.