麻醉性镇痛剂是中枢性药物中一个化学类型繁多、构效关系与作用机制复杂、研究内容极为丰富的领域。长期以来,一直受到人们的重视。到了七十年代中期,由于阿片受体的证实和内源性阿片肽的发现,进一步扩大了该领域的研究视野,对其它神经科学的发展也起了巨大的推动作用。关于阿片药物、阿片肽及阿片受体的研究进展,几乎每年都有专題论述。本文仅从化学角度对近年来的一些主要进展做一概述。 Narcotic analgesics are central medicine in a variety of chemical types, structure-activity relationship and mechanism of action complex, extremely rich in research areas. For a long time, people have always been valued. By the mid-seventies, due to the confirmation of opioid receptors and the discovery of endogenous opioid peptides, the research field in this field was further expanded and played a huge role in promoting the development of other neurosciences. Opinion on opiate drugs, opioid peptides and opioid receptor research progress, almost every year. This article gives a general overview of some of the major advances in recent years from a chemical point of view.