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背景：在中国目前还缺乏针对残疾人的心理健康状况的代表性研究。 目的：在中国武汉具有代表性的严重视觉障碍的人群中，评估抑郁症状的发生率及其相关因素。 方法：采用多阶段分层整群抽样方法，从武汉市残疾人联合会注册的22000名严重视力残疾的人群中抽取1200例。训练有素的调查员使用流行病学研究中心抑郁量表(CES-D)及修订版艾森克人格问卷简式量表(EPQ-RSC)中文版对样本人群进行评估。 结果：成功完成调查的1003个人中轻度，中度和重度抑郁症状的校正患病率分别为8.8%(95%CI=5.7-11.8%)，15.6%(95%CI=12.8-18.5%)和16.0%(95%CI=13.7-18.3%)。多因素逻辑回归分析显示，与严重抑郁症状显著相关的因素有(按重要性顺序)情绪不稳定(OR=5.84，CI=4.19-8.14)，内向性格(OR=2.94，CI=2.10-4.12)，有宗教信仰(OR=2.03，CI=1.06-3.90)，失明(相对于那些仅有视力受损)(OR=1.52，CI=1.09-1.95)，未婚(OR=1.51，CI=1.06-2.15)，以及文化程度低(OR=1.49，CI=1.06-2.10)。 结论：武汉残联注册的所有视碍人员有超过三分之一存在显著临床意义的抑郁症状。这些人几乎没有接受治疗。针对有严重视觉障碍患者的服务，也包括对其他严重的身体或感官残疾患者的服务，应包括开展改善心理健康的活动，定期筛查心理问题，以及必要时对精神障碍进行专业的治疗。“,”Background:There are no representative studies on the mental health status of persons with disabilities in China. Aim:Estimate the prevalence of depressive symptoms and identify the factors associated with depressive symptoms in a representative sample of individuals with serious visually disabilities in Wuhan, China. Methods:A multi-stage stratified cluster sampling method was used to identify 1200 visually disabled individuals from among the 22,000 persons with serious visual disabilities who were registered with the Wuhan Disabled Persons’ Federation. Identified individuals were administered the Center for Epidemiological Studies Depression Scale (CES-D) and the Revised Eysenck Personality Questionnaire-Short Scale for Chinese (EPQ-RSC) by trained interviewers. Results:The adjusted prevalence of mild, moderate and severe depressive symptoms among the 1003 individuals who successfully completed the survey were 8.8%(95%confidence interval [CI]=5.7-11.8%), 15.6%(CI=12.8-18.5%) and 16.0%(CI=13.7-18.3%), respectively. Factors significantly associated with more severe depressive symptoms in the multivariate logistic regression analysis (in order of importance) were emotional instability (OR=5.84, CI=4.19-8.14), introverted personality (OR=2.94, CI=2.10-4.12), having religious beliefs (OR=2.03, CI=1.06-3.90), being blind (versus those who were only visually impaired) (OR=1.52, CI=1.09-1.95), being unmarried (OR=1.51, CI=1.06-2.15), and having less than 10 years of formal education (OR=1.49, CI=1.06-2.10). Conclusions:Over one-third of all individuals with visual disabilities registered with the Disabled Persons’ Federation in Wuhan have clinically significant depressive symptoms. Therefore, services for persons with serious visual disabilities-and for individuals with other types of serious physical or sensory disabilities-should include activities aimed at improving psychological wellbeing, periodic screening for psychological problems and, when needed, professional treatment for mental disorders.