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采用微波辅助合成法快捷、高效地制备了系列咪唑类和吡啶类离子液体,并对其在亲核氟化中的应用进行了研究。结果表明,N-苄基吡啶四氟硼酸盐([bepy]BF4)是一种稳定性高、使用效果好的离子液体。在微波作用下,以N-苄基吡啶四氟硼酸盐和乙腈为共溶剂,以氟化铯为氟化试剂,高效合成了系列含氟化合物。在优化反应条件下,其收率为54.1%～76.3%,反应时间较常规油浴加热最好时可缩短50%以上。
A series of imidazole and pyridine ionic liquids were prepared quickly and efficiently by microwave-assisted synthesis and their applications in nucleophilic fluorination were studied. The results show that N-benzylpyridinium tetrafluoroborate ([bepy] BF4) is a highly stable and effective ionic liquid. Under microwave irradiation, a series of fluorinated compounds were synthesized efficiently using N-benzylpyridinium tetrafluoroborate and acetonitrile as co-solvents and cesium fluoride as fluorinating reagent. Under optimized reaction conditions, the yield is 54.1% ~ 76.3%, and the reaction time can be shortened more than 50% when the heating time is the best.