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Background and Purpose-We sought to examine ischemic stroke subtypes and prevalence of thrombophilia in Brazilian stroke patients. Method-A total of 130 consecutive young and 200 elderly stroke patients were studied. Results-Prevalence of thrombophilia was, respectively: protein S deficiency (11.5%versus 5.5%), protein C deficiency (0.76%versus 1%), resistance to activated protein C (2.3%versus 3.5%), mutation in V Leiden factor (1.5%versus 2%), antithrombin III deficiency (0%versus 0%), lupus anticoagulant (0%versus 0.5%), anticardiolipin antibodies (3%versus 10%; P=0.01), hyperhomocysteinemia (31.5%versus 53.5%; P=0.0001), mutation of the MTHFR gene in homocigosis (10%versus 5%), and heterocigosis (27.6%versus 41.9%; P=0.01). Conclusion -Prothrombotic conditions were more frequent in stroke of undetermined cause.
Background and Purpose-We sought to examine ischemic stroke subtypes and prevalence of thrombophilia in Brazilian stroke patients. Method-A total of 130 consecutive young and 200 elderly stroke patients were studied. Results-Prevalence of thrombophilia was, respectively: protein S deficiency (11.5 % versus 5.5%), protein C deficiency (0.76% versus 1%), resistance to activated protein C (2.3% versus 3.5%), mutation in V Leiden factor (0% vs. 0.5%), anticardiolipin antibodies (3% versus 10%; P = 0.01), hyperhomocysteinemia (31.5% versus 53.5%; P = 0.0001), mutation of the MTHFR gene in homocigosis % versus 5%), and heterocigosis (27.6% versus 41.9%; P = 0.01). Conclusion-Prothrombotic conditions were more frequent in stroke of undetermined cause.