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本工作在离体Wistar大鼠主动脉血管条上,观察到肾上腺髓质素(adrenomedullin,ADM)呈浓度依赖方式抑制血管紧张素Ⅱ(angiotensin Ⅱ,AⅡ)的释放,与对照组比较差异有显著统计学意义(P<0．O5),AⅡ呈浓度依赖方式刺激ADM的释放(P<0．05或0．01),结果提示:血管组织中ADM、AⅡ的释放相互影响,AⅡ可刺激ADM释放,而ADM则抑制AⅡ释放,结合AⅡ、ADM的生物学作用,这种现象可能对维持循环系统功能具有一定的生理、病理生理学意义.
In this study, we observed that adrenomedullin (ADM) inhibits the release of angiotensin Ⅱ (AⅡ) in a concentration-dependent manner in isolated aortic strips of Wistar rats, which is significantly different from the control group Statistically significant (P <0.05), AⅡ stimulated the release of ADM in a concentration-dependent manner (P <0.05 or 0.01). The results suggest that the release of ADM and AⅡ in blood vessels interacts with each other, while AⅡ can stimulate ADM ADM, however, inhibits the release of AII and binds to the biological effects of AII and ADM. This phenomenon may have some physiological and pathophysiological significance in maintaining circulatory system function.