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目的研究肝硬化大鼠小肠黏膜形态及内毒素水平与肠道菌群的关系。方法取雄性SD大鼠20只,共分为3组:未治疗组(L组,n=7)、治疗组(C组,n=7)和正常对照组(N组,n=6)。其中L组为CCl4诱导肝硬化模型,C组为CCl4诱导肝硬化模型同时给予微生态制剂治疗,N组为正常对照组。分别观察小肠黏膜在显微镜下的形态,并检测血浆内毒素。结果未经治疗组大鼠的小肠绒毛明显缩短,炎细胞浸润明显,且内毒素水平明显高于治疗组。结论微生态制剂对肝硬化大鼠有防治作用,抑制肠道内毒素向血液中移位。
Objective To study the relationship between intestinal mucosal morphology and endotoxin levels and intestinal microflora in cirrhotic rats. Methods Twenty male SD rats were divided into three groups: untreated group (n = 7), treatment group (n = 7) and normal control group (n = 6). Among them, L group was CCl4-induced liver cirrhosis model, C group was CCl4-induced cirrhosis model treated with probiotics, and N group was normal control group. The morphological changes of small intestinal mucosa were observed under microscope, and plasma endotoxin was detected. Results In the untreated group, the villus of intestine was significantly shortened, inflammatory cell infiltration was obvious, and the endotoxin level was significantly higher than that of the treatment group. Conclusion The probiotics have preventive and therapeutic effects on cirrhotic rats and inhibit the translocation of intestinal toxins to the blood.