肿瘤干细胞的转移与归巢和肿瘤转移的步骤基本相似,肿瘤的转移可以形象地称为肿瘤干细胞的“归巢”。肿瘤干细胞脱离原发病灶,外渗到细胞外基质,促进血管的生成或细胞内渗,从而进入循环系统,逃避宿主的防御机制,通过趋化作用迁移到特定的血管位点,黏附,然后再外渗出血管而归巢到特定的微环境,形成转移灶。现就肿瘤干细胞的归巢和转移步骤进行综述。 The metastasis of cancer stem cells and homing and tumor metastasis of the steps are similar, the tumor metastasis can be vividly called tumor stem cells “homing ”. Cancer stem cells from the primary lesion, extravasation to the extracellular matrix, and promote the formation of blood vessels or cell infiltration, which enter the circulatory system, evade the host defense mechanism by chemotaxis migration to specific vascular sites, adhesion, and then Ooze out of blood vessels and homing to a specific microenvironment, the formation of metastases. Cancer stem cell homing and transfer steps are reviewed.