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摘 要：［目的］ 探讨非小细胞肺癌(NSCLC)组织中IL-21R与MMP-2的表达及其在NSCLC增长和转移中的作用。［方法］检测并比较60例非小细胞肺癌组织以及60例正常肺组织中IL-21R、MMP-2的表达，比较其阳性表达率与NSCLC患者恶性生物学行为的关系，并进行相关性及预后分析。［结果］ IL-21R、MMP-2阳性率在NSCLC中的表达显著性高于癌旁正常组织(P<0.05)。IL-21R与肿瘤直径有关，IL-21R和MMP-2的表达与淋巴结转移、组织分化、临床分期均相关(P<0.05)。多因素Logistic回归分析显示，IL-21R和MMP-2高水平表达、淋巴结转移、组织学分化、临床分期是NSCLC患者的独立预后因素。［结论］ NSCLC中IL-21R表达和MMP-2表达与肿瘤恶性生物学行为有关，可作为肺癌预后的客观指标。
Abstract: [Objective] To investigate the expression of IL-21R and MMP-2 in non-small cell lung cancer (NSCLC) and their roles in the growth and metastasis of NSCLC. [Methods] The expressions of IL-21R and MMP-2 in 60 non-small cell lung cancer tissues and 60 normal lung tissues were detected and compared. The positive rates of IL-21R and MMP-2 were compared with those of NSCLC patients. Prognosis analysis. [Results] The positive rates of IL-21R and MMP-2 in NSCLC were significantly higher than those in normal tissues (P <0.05). IL-21R was correlated with tumor diameter. The expression of IL-21R and MMP-2 correlated with lymph node metastasis, histological differentiation and clinical stage (P <0.05). Multivariate logistic regression analysis showed that the high expression of IL-21R and MMP-2, lymph node metastasis, histological differentiation and clinical stage were the independent prognostic factors in patients with NSCLC. [Conclusion] The expression of IL-21R and the expression of MMP-2 in NSCLC are related to the malignant biological behavior of the tumor, and can be used as an objective indicator of the prognosis of lung cancer.