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目的探讨鳞状上皮细胞癌抗原Scc、CA125和Ki67在宫颈癌和癌前病变诊断中的价值。方法收集18例正常宫颈、46例宫颈上皮瘤样病变和52例宫颈癌患者,采用化学发光法检测患者血清中Scc、CA125水平,免疫组化SP法检测患者标本中Ki67的表达,并比较3项指标单项检测与联合检测的灵敏度及特异性。结果癌变组患者血清中Scc、CA125水平及Ki67阳性表达率均显著高于瘤变组和正常组(P<0.05);3项指标联合检测的灵敏度及特异性明显高于任一单项指标的灵敏度和特异性。结论 Scc、CA125、Ki67联合检测可作为早期诊断宫颈癌前病变及宫颈癌的标记物,可提高宫颈癌的早期诊断率。
Objective To investigate the value of squamous cell carcinoma antigen Scc, CA125 and Ki67 in the diagnosis of cervical cancer and precancerous lesions. Methods 18 cases of normal cervix, 46 cases of cervical epithelial neoplasia and 52 cases of cervical cancer were collected. The serum levels of Scc and CA125 were detected by chemiluminescence. The expression of Ki67 was detected by immunohistochemical SP method and compared with 3 Item Index Sensitivity and specificity of individual tests and joint tests. Results The serum levels of Scc, CA125 and Ki67 in canceration group were significantly higher than those in the normal control group and the tumorigenic group (P <0.05). The sensitivity and specificity of the combined detection of three indexes were significantly higher than those of any single index And specificity. Conclusion The combined detection of Scc, CA125 and Ki67 can be used as a marker for early diagnosis of cervical precancerous lesions and cervical cancer, which can improve the early diagnosis rate of cervical cancer.