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目的研究骨桥蛋白(osteopontin,OPN)、survivin及bcl-2在宫颈病变中的表达及其临床意义。方法应用免疫组织化学SP法,检测74例宫颈癌、20例高级别上皮内瘤变、20例低级别上皮内瘤变以及24例慢性宫颈炎组织中OPN、survivin、bcl-2的表达。结果 OPN、survivin、bcl-2在四组中阳性率的表达差异均有统计学意义(P<0.01)。组间分析显示宫颈癌、高级别上皮内瘤变、低级别上皮内瘤变与慢性宫颈炎相比,三者阳性率的表达差异均有统计学意义(P<0.05)。低级别上皮内瘤变与宫颈癌之间差异有统计学意义(P<0.05),而高级别上皮内瘤变与宫颈癌之间差异无统计学意义(P>0.05)。OPN的表达与sur-vivin、bcl-2的表达呈正相关(P<0.01)。OPN、survivin的表达与宫颈癌组织学分级、FIGO分期和淋巴结转移呈正相关(P<0.05)。结论 OPN在宫颈癌中高表达,提示OPN与宫颈癌的发生、发展密切相关。宫颈上皮内瘤变及宫颈癌组织中OPN的表达与survivin、bcl-2的表达密切相关。
Objective To study the expression of osteopontin (OPN), survivin and bcl-2 in cervical lesions and its clinical significance. Methods The expressions of OPN, survivin and bcl-2 in 74 cases of cervical cancer, 20 cases of high grade intraepithelial neoplasia, 20 cases of low grade intraepithelial neoplasia and 24 cases of chronic cervicitis were detected by immunohistochemical SP method. Results The positive rates of OPN, survivin and bcl-2 in the four groups were all significantly different (P <0.01). The results of inter-group analysis showed that the positive rates of cervical cancer, high-grade intraepithelial neoplasia, low-grade intraepithelial neoplasia and chronic cervicitis were significantly different (P <0.05). The difference between low grade intraepithelial neoplasia and cervical cancer was statistically significant (P <0.05), but there was no significant difference between high grade intraepithelial neoplasia and cervical cancer (P> 0.05). The expression of OPN was positively correlated with the expression of sur-vivin and bcl-2 (P <0.01). The expressions of OPN and survivin were positively correlated with histological grade, FIGO stage and lymph node metastasis (P <0.05). Conclusion OPN is highly expressed in cervical cancer, suggesting that OPN is closely related to the occurrence and development of cervical cancer. Cervical intraepithelial neoplasia and cervical cancer OPN expression and survivin, bcl-2 expression are closely related.