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目的 研究胸腺瘤中的增殖细胞核抗原 (PCNA )表达 (增殖指数 ,PI)与病理分型和临床分期的相关性。方法 对 5 1例胸腺瘤采用免疫组织化学方法检测PCNA表达 ,并与Masaoka′s临床分期及M M病理组织学分型结果作相关性分析。结果 A组 (非侵袭性胸腺瘤 ) 2 3例 ;B组 (侵袭性胸腺瘤 ) 2 1例 ;C组 (胸腺癌 ) 7例 ,PCNA表达阳性大多为上皮样分化的瘤细胞。临床Ⅰ期 2 5例 ;Ⅱ期 10例 ;Ⅲ期 9例 ;Ⅳ期 7例。统计学分析提示 :PI与病理分型有显著的相关性 (F =7.40 ,P <0 .0 1) ,尤其是A组与B、C组比较有显著性差异 (P <0 .0 1) ,但在B、C组之间无差异 (P >0 .0 5 ) ;PI与临床分期之间亦有显著的相关性 (F =8.5 4,P <0 .0 1) ,其中Ⅰ期与Ⅱ期有显著性差异 (P <0 .0 5 ) ,Ⅰ期与Ⅲ、Ⅳ期之间有非常显著性差异 (P <0 .0 1) ,Ⅱ、Ⅲ、Ⅳ期之间无差异 (P >0 .0 5 )。病理分型与临床分期有显著的相关性 (χ2 =2 9.2 6 ,P <0 .0 1,C =0 .385 )。结论 PCNA表达的检测 (PI)与胸腺瘤的病理分型和临床分期呈正相关 ,反映了胸腺瘤的侵袭潜能和恶性程度。
Objective To investigate the relationship between the expression of proliferating cell nuclear antigen (PCNA) (proliferation index, PI) in thymoma and pathological type and clinical stage. Methods The expression of PCNA was detected by immunohistochemistry in 51 cases of thymoma, and the correlation between the expression of Masaoka’s clinical stage and M M pathological type was analyzed. Results In group A (non-invasive thymoma), 23 cases; group B (invasive thymoma), 21 cases; group C, (thymus carcinoma), 7 cases, PCNA expression was mostly epithelial-like differentiation of tumor cells. There were 25 patients with clinical stage I, 10 patients with stage II, 9 patients with stage III, and 7 patients with stage IV. Statistical analysis suggested that there was a significant correlation between PI and histological type (F = 7.40, P < 0.01), especially in group A and group B and C (P <0.01). However, there was no difference between groups B and C (P > 0.05); there was also a significant correlation between PI and clinical stages (F = 8.54, P < 0.01), of which stage I There was a significant difference in phase II (P < 0.05). There was a significant difference between phase I and phase III and IV (P <0.01). There was no difference between phase II, III and IV (P < 0.05). >0 .0 5 ). There was a significant correlation between pathological type and clinical stage (χ 2 =2 9.2 6 ,P <0 .1 1,C =0.385 ). Conclusion The detection of PCNA expression (PI) is positively correlated with the pathological type and clinical stage of thymoma, reflecting the invasive potential and malignancy of thymoma.