论文部分内容阅读
目的研究隔膜型(membrane obstruction of inferior vena cava,MOIVC)布加综合征(Budd-Chiari syndrome,BCS)患者饮用水中碘浓度与凝血能力的关系。方法收集自2002—2008年间菏泽地区301例隔膜型布加综合征患者。分别于在2008年5月和2009年5月,测定饮水中铝(Al)等16种金属元素浓度和碘浓度。将隔膜型布加综合征患者按水碘浓度分为低水碘(<150μg/L)组、中水碘(150～300μg/L)组和高水碘(>300μg/L)组,并设一正常对照组,每组20人,男女各半。测定凝血酶原时间(PT-time)、凝血酶原时间国际标准化比值(PT-INR)、活化部分凝血酶原时间(APTT-time)、纤维蛋白原时间(Fbg-time)、纤维蛋白原浓度(Fbg-c)、凝血酶时间(TT)、抗凝血酶Ⅲ活力(AT-Ⅲ:A)和DD二聚体(DD-dimer)。结果饮水中所测金属元素均在正常值范围内。有89.37%(269/301)患者分布在高碘(水碘值>150μg/L)地区,32例患者分布在水碘值为12.63～150μg/L的地区。与正常对照组比较,水碘<150μg/L组隔膜型布加综合征患者凝血酶原时间、凝血酶原时间国际标准化比值、纤维蛋白原时间、纤维蛋白原浓度、活化部分凝血酶原时间和凝血酶时间均下降,差异有统计学意义(P<0.05或P<0.01);水碘>150μg/L的两组隔膜型布加综合征患者凝血酶原时间、凝血酶原时间国际标准化比值、活化部分凝血酶原时间、纤维蛋白原时间、凝血酶时间、抗凝血酶Ⅲ活力均升高,纤维蛋白原浓度下降,差异均有统计学意义(P<0.05或P<0.01)。各组DD水平间比较,差异无统计学意义。结论饮用水高碘与隔膜型布加综合征的分布有关,水碘与布加综合征患者凝血功能有关。
Objective To investigate the relationship between iodine concentration and coagulation ability in drinking water of patients with Budd-Chiari syndrome (membrane obstruction of inferior vena cava, MOIVC). Methods A total of 301 patients with septal Budd-Chiari syndrome in Heze area were collected from 2002 to 2008. In May 2008 and May 2009 were measured in drinking water aluminum (Al) 16 kinds of metal element concentration and iodine concentration. According to the concentration of water iodine, patients with diaphragm-type Budd-Chiari syndrome were divided into low water iodine group (150μg / L), middle water iodine group (150-300μg / L) and high water iodine group (> 300μg / L) A normal control group of 20 people each, half male and half female. Prothrombin time, PT-INR, APTT-time, Fbg-time, fibrinogen concentration (Fbg-c), thrombin time (TT), antithrombin III activity (AT-III: A) and DD dimer (DD-dimer). Results of drinking water measured in the normal range of metal elements. There were 89.37% (269/301) patients with high iodine (water iodine value> 150μg / L) and 32 patients with iodine value of 12.63-150μg / L. Compared with the normal control group, prothrombin time, prothrombin time international normalized ratio, fibrinogen time, fibrinogen concentration, activated partial prothrombin time and Thrombin time, the difference was statistically significant (P <0.05 or P <0.01); water iodine> 150μg / L in patients with septum Budd-Chiari syndrome septum time, prothrombin time international standardization ratio, Activated partial prothrombin time, fibrinogen time, thrombin time, antithrombin Ⅲ activity were elevated, fibrinogen concentration decreased, the difference was statistically significant (P <0.05 or P <0.01). There was no significant difference in DD level between groups. Conclusion High iodine in drinking water is related to the distribution of septum Budd-Chiari syndrome, and water iodine is associated with coagulation in patients with Budd-Chiari syndrome.