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目的制备匹多莫德磷脂复合物并对复合物进行鉴别。方法以结合率为评价标准,结合单因素考察与正交试验设计法确定匹多莫德磷脂复合物的制备方法,并采用红外分析法、差式扫描量热分析、X-射线衍射分析鉴别所制得的复合物。结果匹多莫德磷脂复合物反应条件如下:乙醇为反应溶剂,匹多莫德与磷脂的投料摩尔比为1∶1,反应液中药物浓度为8 mg·m L?1,于60℃下磁力搅拌1 h。复合物红外图谱发生变化;差热扫描显示复合物的相变温度改变;X-射线衍射分析显示复合物呈现无定型特征。结论确定制备匹多莫德磷脂复合物的最佳工艺,匹多莫德与磷脂形成复合物,结构不同于单体及物理混合物。
Objective To prepare podopod phospholipid complex and identify the complex. Methods The preparation method of pidotimod phospholipid complex was established by combining the single factor test and orthogonal design method with the binding rate as the evaluation standard. The infrared spectroscopy, differential scanning calorimetry and X-ray diffraction analysis were used to identify the phospholipid complex. The resulting composite. Results The reaction conditions of the pidotimod phospholipid complex were as follows: ethanol was the reaction solvent, the molar ratio of pidotimod to phospholipid was 1: 1, and the concentration of drug in the reaction solution was 8 mg · m L -1. Magnetic stirring 1 h. Complex infrared spectra change; differential scanning calorimetry shows phase transition temperature change; X-ray diffraction analysis showed amorphous complex features. Conclusion The optimum conditions for the preparation of pidotimod phospholipid complexes were determined. Pidotimod and phospholipid formed a complex with a different structure from the monomer and the physical mixture.