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从对免疫系统功能和宿主其他方面防卫功能的影响来讲,铁是最重要的微量营养素之一。无论铁过多或铁缺乏都可能产生不良影响。一、铁过多和感染细菌需要足量的铁,以保证其有足够的能力生长、复制、产生和释放某些外毒素。某些细菌能分泌可络合环境中铁的含铁细胞,从而增加细菌对铁的利用能力。在动物或人的感染过程中,有两种主要机制使微生物的获铁能力受到急剧限制:(1)铁被迅速蓄存于机体组织
Iron is one of the most important micronutrients in terms of its effects on immune system function and other aspects of host defense. Irrespective of iron or iron deficiency may have adverse effects. First, iron overload and infection of bacteria need sufficient iron to ensure that they have sufficient ability to grow, replicate, produce and release some exotoxin. Some bacteria can secrete iron-containing cells that can complex iron in the environment, thereby increasing the bacteria’s ability to utilize iron. In animal or human infection, there are two main mechanisms that limit the ability of microorganisms to gain access to iron dramatically: (1) iron is rapidly stored in body tissues