1B型糖尿病(DM)又称特发性1型DM或非典型DM,为非自身免疫损伤所致,但病因尚不明。其临床特点为:发病急骤,高血糖与糖化血红蛋白Alc不成比例,血中胰岛自身抗体阴性。血、尿C-肽水平降低,无胰腺炎,但是血清胰淀粉酶及弹性蛋白酶水平升高,有常染色体显性遗传趋势。治疗应以胰岛素为主,辅以口服降糖药、饮食控制及体育锻炼。 Type 1B diabetes mellitus (DM), also known as idiopathic type 1 DM or atypical DM, is caused by non-autoimmune damage, but the cause is unknown. Its clinical features are: sudden onset, high blood sugar and glycosylated hemoglobin Alc is disproportionate, blood islet autoantibodies negative. Blood, urine C-peptide levels decreased, no pancreatitis, but serum pancreatic amylase and elastase levels, there is an autosomal dominant genetic trend. Treatment should be based on insulin, supplemented by oral hypoglycemic agents, diet control and physical activity.