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目的：探讨急性心肌梗死（ Ａ Ｍ Ｉ）患者血清一氧化氮（ Ｎ Ｏ）含量变化及其临床意义。方法：在２８例 Ａ Ｍ Ｉ患者接受尿激酶静脉溶栓治疗前及治疗后３ ｈ 分别测定其血清一氧化氮（ Ｎ Ｏ）、超氧化物岐化酶（ Ｓ Ｏ Ｄ）及丙二醛（ Ｍ Ｄ Ａ）的含量变化。结果：溶栓治疗后３ ｈ 的 Ｎ Ｏ、 Ｓ Ｏ Ｄ 含量较治疗前含量显著减少（ Ｐ ＜ ０．０５）。 Ｍ Ｄ Ａ 含量显著增加（ Ｐ ＜ ０．０５）。尤以冠状动脉再通组 Ｎ Ｏ、 Ｓ Ｏ Ｄ 含量减少（ Ｐ ＜ ０．０１）， Ｍ Ａ Ｄ 含量增加（ Ｐ ＜ ０．０１）更明显。而未通组在治疗前后的 Ｎ Ｏ、 Ｓ Ｏ Ｄ、 Ｍ Ｄ Ａ 含量无显著性差异（ Ｐ ＞ ０．０５）。结论： Ｎ Ｏ、 Ｓ Ｏ Ｄ 含量减少， Ｍ Ａ Ｄ 含量增加与缺血心肌再灌注损伤有关，在对 Ａ Ｍ Ｉ患者行溶栓治疗同时，应同时积极采取抗氧化治疗。
Objective: To investigate the change of serum nitric oxide (NO) level in patients with acute myocardial infarction (AMI) and its clinical significance. Methods: Serum nitric oxide (NO), superoxide dismutase (SOD) and malondialdehyde (MDA) were measured in 28 AML patients before and after 3 hours of intravenous thrombolysis of urokinase M D A) content changes. Results: The content of NO and SOD after 3 hours of thrombolytic therapy was significantly lower than that before treatment (P <0.05). M D A content increased significantly (P <0.05). In particular, the levels of N O, S O D in coronary reperfusion group were decreased (P <0.01), and M A D content was increased (P <0.01). However, there was no significant difference in N O, S O D and M D A before and after treatment in the untreated group (P> 0.05). CONCLUSION: The decrease of NO, SOD and the increase of MDA content are associated with myocardial ischemia-reperfusion injury. Anti-oxidative therapy should be taken simultaneously with thrombolysis in A M I patients.