Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergisti

来源 :癌症生物学与医学:英文版 | 被引量 : 0次 | 上传用户：guangmingkoxiuluo

【摘要】

：

Objective:Natural extracts,including nobiletin,have been reported to enhance the efficacy and sensitivity of chemotherapeutic drugs.However,whether and how nobi

【作者】

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Tingting Chen Liu Liu Yonghong

【机构】

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DepartmentofUrology,DepartmentofNephrology,DepartmentofReproductiveMedicine,DepartmentofInfectiousDi

【出处】

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癌症生物学与医学:英文版

【发表日期】

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2021年1期

【关键词】

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NOBILETIN SKP2 palbociclib SYNERGISTIC renal cell carcinoma

【基金项目】

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supported by the National Natural Science Foundation of China(Grant Nos.81772702 and 81502214)

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Objective:Natural extracts,including nobiletin,have been reported to enhance the efficacy and sensitivity of chemotherapeutic drugs.However,whether and how nobiletin affects tumor growth and progression in renal cell carcinoma(RCC)are still unclear.Method

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Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergisti

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