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目的 :探讨吸入呋塞米对支气管哮喘 (哮喘 )病人气道反应性的影响。方法 :缓解期哮喘病人4 0例 ,随机分为A ,B 2组 ,每组各 2 0例。试验分 2次隔日交叉吸入 0 .9%氯化钠注射液 4mL或呋塞米 4 0mg后予组胺吸入激发试验。结果 :2组病人吸入 0 .9%氯化钠注射液后的组胺PC2 0 FEV1差异无显著意义 (P >0 .0 5) ;吸入呋塞米后的组胺PC2 0 FEV1差异亦无显著意义 (P >0 .0 5) ;但 2组病人吸入呋塞米后的组胺PC2 0 FEV1均显著高于其吸入0 .9%氯化钠注射液后的组胺PC2 0 FEV1(均P <0 .0 5)。结论 :吸入呋塞米可抑制哮喘病人的气道高反应性。
Objective: To investigate the effect of inhaled furosemide on airway responsiveness in patients with bronchial asthma (asthma). Methods: 40 asthmatic patients were randomly divided into A and B 2 groups, 20 cases in each group. Tests were divided into 2 times the next day crossed with 0.9% sodium chloride injection 4mL or furosemide 40mg after histamine inhalation challenge test. Results: There was no significant difference in histamine PC20 FEV1 after 0.9% sodium chloride injection between the two groups (P> 0.05). There was no significant difference in histamine PC20 FEV1 after inhaling furosemide (P> 0.05). However, the histamine PC2 0 FEV1 after induction of furosemide in both groups was significantly higher than that of histamine PC2 0 FEV1 (both P <0 .0 5). Conclusion: Furosemide inhalation can inhibit airway hyperresponsiveness in asthmatic patients.