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睾丸支持细胞(Sertoli cells)在精子发生过程中具有支持、营养生殖细胞的作用。近10多年来,人们发现支持细胞还有分泌液体,产生类固醇,吞噬残留物,组成渗透屏障及分泌雄激素结合蛋白和抑制素,参与丘脑下部—垂体—睾丸轴的神经内分泌调节,维持精子发生过程等多种功能。本文拟对支持细胞的功能作一概述,并着重介绍支持细胞构成血液—睾丸屏障的重要性以及其分泌雄激素结合蛋白和抑制素的研究。
Sertoli cells have the role of supporting vegetative germ cells during spermatogenesis. In the past 10 years or so, it has been found that the supporting cells also secrete fluid, produce steroids, devour residues, form osmotic barriers and secrete androgen-binding protein and inhibin, participate in neuroendocrine regulation of hypothalamus-pituitary-testis axis and maintain spermatogenesis Process and other functions. This article is intended to outline the function of supporting cells and highlight the importance of supporting the cells to form the blood-testis barrier and their ability to secrete androgen-binding proteins and inhibins.