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本工作对9例正常育龄妇女与13例口服复方孕素1号片(一种新型的长效避孕药)妇女血浆中 FSH,LH,E_2-17β与孕酮进行了放射免疫测定。结果表明,药物使月经周期中的激素水平发生显著变化。同对照组正常值相比,服药后的激素变化可分三种类型。无排卵型(9例),排卵型(2例)与延迟排卵型(2例)。文中对各型激素变化特点作了描述。此外,根据本工作看来,作者以前观察到的孕素1号引起子宫内膜早熟,可能是药物的孕激素活性对内膜直接作用的结果。
In this study, radioimmunoassay of FSH, LH, E_2-17β and progesterone in plasma of 9 normal women of childbearing age and 13 oral tablets of compound progestogen 1 (a new long-acting contraceptive) were performed in women. The results show that the drug causes significant changes in hormone levels during the menstrual cycle. Compared with the normal control group, after taking the hormone changes can be divided into three types. Anovulatory (n = 9), Ovulation (n = 2) and Delayed Ovulation (n = 2). The article describes the characteristics of various types of hormones. In addition, it appears from the present work that the progestin 1 observed by the author previously caused endometrial precanceration, which may be the result of the direct effect of the progestin activity of the drug on the intima.