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目的:探讨IL-6、IL-8和IL-10水平与肝硬化患者预后之间的关系.方法:采用ELISA法分别测定肝硬化患者治疗前后的IL-6、IL-8和IL-10水平.结果:肝硬化患者的IL-6、IL-8、IL-10水平较正常对照组显著升高.治疗后肝功能减退组的IL-6、IL-8水平较治疗前有显著升高,IL-10水平升高不显著,而治疗后肝功能恢复组的IL-6、IL-8水平较治疗前降低,与治疗前有显著差异,而IL-10水平则明显升高,表明IL-6、IL-8、IL-10与肝硬化预后有关.结论:IL-6、IL-8、IL-10与肝硬化患者预后有关,其血清水平可作为判断肝硬化患者预后的指标之一.
Objective: To investigate the relationship between the levels of IL-6, IL-8 and IL-10 and the prognosis of patients with cirrhosis.Methods: The levels of IL-6, IL-8 and IL-10 in cirrhotic patients before and after treatment were measured by ELISA Results: The levels of IL-6, IL-8 and IL-10 in patients with liver cirrhosis were significantly higher than those in normal control group, and the levels of IL-6 and IL-8 in patients with liver dysfunction after treatment were significantly higher than those before treatment The level of IL-10 was not significantly increased, but the levels of IL-6 and IL-8 in the liver function recovery group after treatment were lower than those before treatment, but significantly different from those before treatment, while the level of IL-10 was significantly increased, IL-8 and IL-10 were correlated with the prognosis of cirrhosis.Conclusion: IL-6, IL-8 and IL-10 are related to the prognosis of patients with cirrhosis, and their serum levels can be used as one of the prognostic indicators in patients with cirrhosis.