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目的:通过检测喉鳞癌组织中COX-2和VEGF-C的表达情况,探讨其与喉癌各临床病理特征的关系。方法:免疫组化S-P方法检测64例喉鳞癌及33例正常喉粘膜组织中COX-2和VEGF-C的表达,分析二者相关关系,并分析其与喉癌临床各参数的相关性。结果:在喉鳞癌组织中COX-2和VEGF-C的表达较高,其阳性率分别为76.56%、96.77%,与正常喉粘膜中9.09%、3.03%相比差异均具有显著性意义(P<0.01)。COX-2和VEGF-C在声门上型、分化程度低以及晚期喉癌中表达阳性率高(分别为57.58%、96.77%、83.67%和79.07%、90.32%、100%),而在其他类型中表达低,差异具有显著性意义(P<0.01),COX-2和VEGF-C表达呈正相关。结论:COX-2、VEGF-C的高表达与喉鳞癌的临床密切相关,其对于喉癌的淋巴转移及预后均有重要意义。
OBJECTIVE: To detect the expression of COX-2 and VEGF-C in laryngeal squamous cell carcinoma (LSCC) and to investigate the relationship between the expression of COX-2 and VEGF-C and the clinicopathological features of laryngeal carcinoma. Methods: The expressions of COX-2 and VEGF-C in 64 cases of laryngeal squamous cell carcinoma and 33 cases of normal laryngeal squamous cell carcinoma were detected by immunohistochemical S-P method. The correlation between the expression of COX-2 and VEGF-C was analyzed. Results: The positive rates of COX-2 and VEGF-C in laryngeal squamous cell carcinoma were 76.56% and 96.77%, respectively, which were significantly different from those in normal laryngeal mucosa (9.09% and 3.03% P <0.01). The positive rates of COX-2 and VEGF-C in supraglottic, low differentiation and advanced laryngeal carcinoma were higher (57.58%, 96.77%, 83.67% and 79.07%, 90.32% and 100%, respectively) The expression of COX-2 and VEGF-C was positively correlated with the expression of COX-2 and VEGF-C. Conclusion: The high expression of COX-2 and VEGF-C is closely related to the clinical significance of laryngeal squamous cell carcinoma, which is of great significance for lymph node metastasis and prognosis of laryngeal carcinoma.