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目的以光吸收值≥0.25u的时间百分比(total time percent with absorbance value≥0.25u,AV0.25)作为诊断标准,评价十二指肠内胆红素光吸收值监测在胆道闭锁(biliary atresia,BA)诊断中的应用价值。方法分别以AV0.25=0及AV0.25>0作为BA及婴儿肝炎综合征(infantile hepatitis syndrome,IHS)的诊断标准,对23例BA患儿(男15例,女8例,年龄2~17周,平均6.5周)及42例IHS患儿(男29例,女13例,年龄3~18周,平均8.4周)进行诊断试验,评价其在BA早期诊断中的应用价值。结果胆红素光吸收值监测在BA诊断中的准确率、特异度、阳性预测值、阴性预测值及正确诊断指数分别为95%,93%,88%,100%,0.93。结论以AV0.25=0作为诊断标准的十二指肠内胆红素光吸收值监测为BA提供了一种新的、准确的诊断方法。
Objective To evaluate the value of bilirubin absorbance monitoring in biliary atresia (total time percent with absorbance value≥0.25u, AV0.25) as the diagnostic criteria, BA) diagnostic value of the application. Methods According to the diagnostic criteria of AV0.25 = 0 and AV0.25> 0, respectively, in BA and infantile hepatitis syndrome (IHS), 23 cases of BA children (15 males and 8 females, 17 weeks with an average of 6.5 weeks) and 42 children with IHS (29 males and 13 females, aged 3-18 weeks, mean 8.4 weeks) were included in this study. The diagnostic value of this method was evaluated in the early diagnosis of BA. Results The accuracy, specificity, positive predictive value, negative predictive value and correct diagnostic index of bilirubin absorbance monitoring in diagnosis of BA were 95%, 93%, 88%, 100% and 0.93, respectively. Conclusion The monitoring of intraduodenal bilirubin absorbance using AV0.25 = 0 as diagnostic criteria provides a new and accurate diagnostic method for BA.