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目的:分析嗜铬细胞瘤/副神经节瘤（PPGL）患者肿瘤切除术后复发和转移的发生情况及其临床特征。方法:本研究为回顾性随访研究，以2008—2016年于北京协和医院就诊并行肿瘤切除的PPGL患者为研究对象，共157例。获得患者基本情况［诊断年龄、性别、身高、体重和体质指数（BMI）］，PPGL发病情况（起病年龄、病程、家族史、肿瘤位置、肿瘤是否双侧或多发、术前血压），PPGL肿瘤临床和病理特点（肿瘤大小，术中是否有粘连、侵袭或浸润，术后病理包膜是否光滑完整、有无浸润生长、囊变坏死以及Ki-67指数），以及实验室检查结果［术前24 h尿去甲肾上腺素（NE）、肾上腺素（E）、多巴胺（DA）］等，根据门诊随访或电话随访获得患者术后复发和转移情况，并比较出现复发或转移的患者与未复发转移患者之间的基本情况、发病情况、肿瘤的临床和病理特点，以及实验室检查结果等。结果:157例患者的年龄为（42.4±13.4）岁，男69例，女88例。其中103例为嗜铬细胞瘤（PCC），54例为副神经节瘤（PGL），随访时间为（9.5±2.0）年。PCC患者中，13例（12.6%）术后复发，9例（8.7%）远处转移；与未发生复发转移的患者相比，复发患者起病年龄更小［（27.3±15.7）岁比（39.3±12.2）岁，n P=0.003］，病程更长［48.0（23.0，141.0）月比12.0（4.0，60.0）月，n P=0.010］；出现远处转移患者的肿瘤体积更大［8.0（6.1，12.8）cm 比 5.0（4.0，7.0）cm，n P=0.027］。PGL的患者中，8例（14.8%）术后复发，5例（9.3%）远处转移；与未发生复发转移的患者相比，复发患者病程更长［90.0（36.3，165.0）月比24.0（8.0，72.0）月，n P=0.009］，原发肿瘤为多发病灶的比例更高［4/8比4.4%（2例），n P=0.003］；远处转移患者术前舒张压更高［（146.0±32.1）mmHg比（120.6±25.3）mmHg，n P=0.043］（1 mmHg=0.133 kPa），原发肿瘤为多发病灶的比例也更高［2/4比4.4%（2例），n P=0.029］。n 结论:PPGL患者术后容易出现复发或转移。术后复发或出现远处转移的PPGL患者起病年龄更小，病程更长，肿瘤体积更大，且多发病灶更为多见。“,”Objective:The purpose of this study is to investigate the incidence of recurrence or metastasis of pheochromocytoma/paraganglioma (PPGL) patients after primary tumor resection, and to compare the differences of clinical indicators between patients with or without recurrence or metastasis.Methods:This study is a retrospective study. All 157 patients were followed up after tumor resection in Peking Union Medical College Hospital from 2008 to 2016. We obtained the basic information [age of diagnosis, gender, height, weight and body mass index (BMI)], the onset status of PPGL (age of onset, course of disease, family history, tumor location, whether the tumor is bilateral or multiple, and preoperative blood pressure), clinical and pathological features of PPGL tumor (tumor size, whether it could adhere, invade or infiltrate during operation, whether the tumor capsule is smooth and complete on the postoperative pathological diagnosis, whether there is infiltration growth and cystic necrosis on tumor pathology and Ki-67 index), and laboratory examination results [24 hours urinary norepinephrine (NE), epinephrine (E), dopamine (DA) before operation]. According to the outpatient or telephone follow-up, the postoperative incidences of recurrence and metastasis were explored, and the basic information, status of onset, clinical and pathological characteristics of tumors, and laboratory test results of patients were compared.Results:A total of 157 patients, 69 males and 88 females, were with an average age of (42.4±13.4) years old. There were 103 patients with PCC and 54 with PGL. The average follow-up time was (9.5±2.0) years. Of the 103 patients with PCC, 13 (12.6%) had postoperative recurrence and 9 (8.7%) had distant metastasis. Compared with the patients without recurrence and metastasis, the onset age of the 13 patients with recurrence was younger [(27.3±15.7) years vs (39.3±12.2) years, n P=0.003], the course of disease was longer [48.0 (23.0, 141.0) months vs 12.0 (4.0, 60.0) months, n P=0.010]. The tumor size of 9 patients with distant metastasis was larger [8.0 (6.1, 12.8) cm vs 5.0 (4.0, 7.0) cm, n P=0.027]. Of the 54 patients with PGL, 8 (14.8%) had postoperative recurrence and 5 (9.3%) had distant metastasis. Compared with the patients without recurrence and metastasis, the course of disease of the 8 patients with recurrence was longer [90.0 (36.3, 165.0) months vs 24.0 (8.0, 72.0) months, n P=0.009], and the proportion of primary tumors with multiple lesions was higher (4/8 vs 4.4%, n P=0.003). The preoperative diastolic blood pressure was higher in 5 patients with distant metastasis [(146.0±32.1) mmHg vs (120.6±25.3) mmHg, n P=0.043] (1 mmHg=0.133 kPa), and the proportion of primary tumors with multiple lesions was higher (2/4 vs 4.4%, n P=0.029).n Conclusion:PPGL patients are prone to have recurrence or metastasis. PPGL patients with postoperative recurrence or distant metastasis had younger onset age, longer course of disease, larger tumor size and higher proportion of multiple lesions.