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目的研究持续吸入小剂量皮质激素治疗儿童哮喘的临床疗效及其对生长发育、骨与钙磷代谢的影响。方法将４３例哮喘儿童随机分为３组，分别为吸入不同剂量（１００～２００μｇ／ｄ，３００～４００μｇ／ｄ）的ＢＤＰ治疗组与对照组。疗程６～８月。观察临床疗效。实行家庭峰流速仪（ＰＥＦ）监测。在疗程开始与结束时分别测：血Ｃａ、Ｐ、ＡＫＰ、空腹晨尿Ｃａ／Ｃｒ；单光子骨密度仪测量桡、尺骨骨密度；标准差记分法评价身高、体重、身高增长速度情况。结果持续吸入ＢＤＰ６～８个月临床症状得到良好控制，ＰＥＦ值明显改善。生长发育、骨与钙磷代谢未受影响。结论持续吸入小剂量激素可作为一线药物用于哮喘儿童的预防与治疗。
Objective To study the clinical efficacy of continuous inhalation of small doses of corticosteroids in children with asthma and its effects on the growth and development, bone and calcium and phosphorus metabolism. Methods Forty-three asthmatic children were randomly divided into three groups: BDP treatment group and control group with different doses (100-200 μg / d, 300-400 μg / d) respectively. Course 6 to August. Observe the clinical effect. The implementation of family peak velocity meter (PEF) monitoring. At the beginning and the end of the treatment, the levels of Ca, P and AKP in blood and Ca / Cr in fasting morning urine were respectively measured. The radial and ulnar bone mineral density were measured by single photon densitometer. The standard deviation score method was used to evaluate the height, weight and height growth rate. Results Continuous inhalation of BDP 6 to 8 months clinical symptoms were well controlled, PEF value was significantly improved. Growth and development, bone and calcium and phosphorus metabolism was not affected. Conclusions Continuous inhalation of small doses of hormone can be used as a first-line drug for the prevention and treatment of asthmatic children.