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目的 了解铅对作业工人甲状腺功能的影响。方法 选择暴露于铅作业环境下的人群 ,了解工人作业工龄 ,采用火焰原子吸收光谱法测定其作业环境中铅浓度 ,用原子吸收光谱法测定作业工人血铅 (PbB)浓度 ,用血液锌原卟啉测定仪测定血锌原卟啉 (ZPP)浓度 ,用放射免疫分析法检测血清中促甲状腺素 (TSH)、三碘甲状腺原氨酸 (T3)、甲状腺素 (T4 )、游离T3(FT3)、游离T4 (FT4 ) 5项甲状腺功能指标。结果 血铅 >2 .88μmol/L时 ,T3[(1 .54± 0 .39)nmol/L]、FT3[(5 .50± 1 .2 6)pmol/L]含量明显低于血铅 (1 .92～ 2 .88) μmol/L组 [T3(1 .71± 0 .45)nmol/L、FT3(6 .1 2± 1 .64)pmol/L] ,差异有显著性(P <0 .0 5)。铅作业工龄长短对甲状腺激素 (TH)含量未见明显影响。结论 高浓度血铅可能抑制了T4 的脱碘 ;铅作业工龄对甲状腺功能未见明显影响
Objective To understand the effect of lead on thyroid function in workers. Methods The workers exposed to lead working environment were selected to understand the working age of workers. The concentration of lead in working environment was determined by flame atomic absorption spectrometry. The concentration of blood lead (PbB) was measured by atomic absorption spectrometry. The concentration of ZPP was measured by radioimmunoassay. Serum levels of TSH, T3, T4, FT3, , Free T4 (FT4) 5 thyroid function indicators. Results The levels of T3 [(1.54 ± 0.39) nmol / L] and FT3 [(5.50 ± 1.26) pmol / L] were significantly lower than those of blood lead 1 .92 ~ 2.88) μmol / L group [T3 (1.71 ± 0.45) nmol / L and FT3 (6.61 ± 1.64) pmol / L], the difference was significant (P < 0 .0 5). Lead working length of the length of thyroid hormone (TH) content was not significantly affected. Conclusion High concentrations of blood lead may inhibit the deiodination of T4. Lead working age has no obvious effect on thyroid function