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基于多层电介质模型,对于适应于球形生物细胞的脉冲电场,提出了一种等效电路模型,在相同频域下,内膜和外膜的变化趋势相同,频域分析表明,不同频谱场将引起不同的生物医学效应.我们针对癌症细胞计算了跨膜电压,并讨论了脉冲和跨膜电压以及阻抗的关系.结果表明不同的频域和不同的持续时间对细胞的内膜和外膜有选择性的影响,时域和频域的分析显示,在细胞上有一个窗口,当持续时间在10~(-8)~10~(-6)s之间,细胞内膜的电压将高于细胞外膜的电压.窗口效应为解释生物细胞的脉冲电学效应提供了一种参考思路.
Based on the multi-layer dielectric model, an equivalent circuit model is proposed for the pulsed electric field that adapts to spherical biological cells. In the same frequency range, the change tendency of the intima and the adventitia is the same. The frequency-domain analysis shows that different spectral fields Causing different biomedical effects.We calculated the transmembrane voltage for cancer cells and discussed the relationship between pulse and transmembrane voltage and impedance.The results show that different frequency and duration of the cell membrane and endometrial Selectivity, time domain and frequency domain analysis showed that there was a window in the cell. When the duration was between 10 -8 and 10 -6, the voltage in the cell membrane would be higher than The voltage of the extracellular membrane. The window effect provides a reference idea for explaining the pulsed electrical effect of biological cells.