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新生儿胃肠道因胎粪所引起的梗阻其严重程度从可能需要手术的浓度胎粪综合征直到生后24小时不能排出胎粪而能自然缓解的胎粪栓综合征。为了识别与有关此病的病因,我们检查了8名在新生儿期诊断为胎粪性肠梗阻的婴儿的产前病历。病人和结果本院新生儿监护抢救室在十二个月期间治疗400名婴儿中只8名诊断为胃肠道胎粪性肠梗阻。8名婴儿出生体重均低于第3百分位。他们的母亲在妊娠24～30周时,因诊断有严重宫内发育迟缓而入院。胎儿体格和染色体正常;筛查毒血症、风疹、巨细胞病毒、疱疹和自家抗体均阴性,腹围在相应孕期的正常范围第5百分位以下。每个胎儿都有肠超声过强,其定义为:腹部下半部肝与膀胱之间,超声性与骨骼相似之块状物。每个胎儿还有羊水过少症。多普勒超声图显示子宫胎盘循环的抵抗指数(resist-
The severity of obstruction due to meconium in the neonatal gastrointestinal tract can be naturally relieved with meconium-bolt syndrome from concentrations of meconium syndrome that may require surgery until 24 hours after birth. To identify the cause of the disease, we examined the prenatal records of 8 infants diagnosed with meconium ileus during the neonatal period. PATIENTS AND RESULTS Eight out of 400 infants treated in our neonatal care emergency room during the 12-month period were diagnosed as gastrointestinal meconium ileus. The birth weight of 8 infants was lower than the 3rd percentile. Their mothers were hospitalized 24 to 30 weeks of gestation due to a diagnosis of severe intrauterine growth retardation. Fetal physical and chromosomal normal; screening for sepsis, rubella, cytomegalovirus, herpes and their own antibodies were negative, the abdominal circumference in the corresponding normal range of pregnancy below the 5th percentile. Each fetus has bowel hyperactivity, which is defined as the lump between the liver and the bladder in the lower half of the abdomen that is similar to bone. Each fetus also have oligohydramnios. Doppler ultrasound showed uterine placental circulation resistance index (resist-