【摘 要】
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目的:观察艾烟对昆明小鼠(KM)的急性毒性。方法:选用采用全身整体暴露的方法,应用全自动动式染毒柜CSED-A,将3组KM小鼠(n=36,雌雄各半),分别暴露于遮光率为85%、65%、50%的艾
【机 构】
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北京中医药大学中医学院,北京中医药大学针灸推拿学院,北京中医药大学附属护国寺中医医院,华北电网有限公司北京电力医院,重庆渝北区中医院,中国人民解放军军事医学科学院,
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目的:观察艾烟对昆明小鼠(KM)的急性毒性。方法:选用采用全身整体暴露的方法,应用全自动动式染毒柜CSED-A,将3组KM小鼠(n=36,雌雄各半),分别暴露于遮光率为85%、65%、50%的艾烟中,记录各组小鼠的毒性反应以及最终艾烟暴露时间,进而回归分析得出各组半数致死时间(LT50)。结果:小鼠表现为呼吸困难,多泪和明显增多的无色的鼻腔分泌物,运动失调,强直性抽搐和角弓反张。85%、65%、50%艾烟对雄鼠的LT50(38.59、283.05、315.87min)低于雌性(51.62、298.46、386.99min);全体的85%、65%、50%艾烟的LT50分别为45.77、295.33、303.94min。结论:超高浓度的艾烟在足够长的暴露时间导致小鼠死亡,但不支持临床接触艾烟即存在安全隐患,本实验为后期艾烟安全剂量和有效剂量的研究提供参考。
Objective: To observe the acute toxicity of Ai Yan to Kunming mice (KM). Methods: Three groups of KM mice (n = 36, half male and half female) were exposed to shading rates of 85%, 65%, respectively, using the automatic whole body exposure system CSED- 50% of Ai smoke, the toxicity of each group of mice recorded as well as the final smoke exposure time, and then regression analysis showed that each group half the lethal time (LT50). Results: Mice presented with non-colored nasal secretions, dyskinesia, tonic convulsions and angle arch anti-dilation with dyspnea, multiple tears and a marked increase. The LT50 (85.5%, 65%, 50%) of male mice at 85%, 65%, 50% 45.77, 295.33, 303.94 min. CONCLUSIONS: Ultra-high concentrations of Ai smoke cause mice to die after a long enough exposure time, but do not support clinical exposure to Ai smoke, which is a potential safety hazard. This study provides a reference for the safe dose and effective dose of Ai.
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