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中药生物药剂学分类系统(CMMBCS)的优势之一,是将分类归属的研究层面从单成分扩展到中药多成分,进而从多成分扩展到中药整体研究层面。该研究以黄连提取物中的生物碱为主要研究对象,探究生物碱单一成分及黄连提取物中各生物碱成分的水溶解性及肠渗透性变化规律,并对黄连提取物整体做中药生物药剂学分类系统归属研究。其中采用经典摇瓶法和高效液相色谱法测定生物碱单一成分及提取物中各生物碱成分的溶解度变化及分类,采用在体单向肠灌流法进行生物碱吸收定量研究,同时采用自定义权重系数法对黄连提取物整体进行渗透系数计算。
One of the advantages of the CMMBCS is to extend the research aspects that belong to the classification from single components to multi-components of TCM, and then extend from multiple components to the overall research level of TCM. The study takes the alkaloids in the extract of Coptidis Rhizoma as the main research object, explores the water solubility and the intestinal permeability of alkaloids in the alkaloids as a single component and the Coptis extract, Study Classification System. Which uses classical shake flask method and high performance liquid chromatography determination of alkaloid single component and the solubility of alkaloids in extracts and classification of changes in the use of bulk mono-intestinal perfusion method alkaloid absorption quantitative study at the same time using a custom Permeability Coefficient Method for Total Permeation Coefficient of Coptis Chinensis Franch.