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Fas/FasL是凋亡信号传导的一条途径。正常妊娠滋养细胞表达FasL诱导母体活化淋巴细胞凋亡是胎儿免疫耐受的重要机制。Fas/FasL在妊娠滋养细胞疾病中表达的研究刚起步。葡萄胎滋养细胞表达FasL引起蜕膜Fas+淋巴细胞凋亡促进免疫耐受和滋养细胞的存活。恶性滋养细胞Fas介导的凋亡敏感性降低及与FasL同时表达反击淋巴细胞可传授免疫赦免。Fas/FasL可能代表一个机制,通过这个机制恶性滋养细胞抵抗凋亡,逃避免疫监视和发生转移。
Fas / FasL is a pathway of apoptosis signaling. Normal gestational trophoblast expression of FasL induced maternal activation of lymphocyte apoptosis is an important mechanism of fetal immune tolerance. Fas / FasL expression in gestational trophoblastic disease has just begun. Hydatidiform mole trophoblasts express FasL causing decidual Fas + lymphocyte apoptosis to promote immune tolerance and trophoblast survival. Decreased sensitivity of Fas-mediated apoptosis of malignant trophoblast cells and simultaneous expression of FasL and counterattacking lymphocytes can be used to impart immune pardon. Fas / FasL may represent a mechanism by which malignant trophoblasts resist apoptosis, evade immune surveillance and metastasis.