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昔多芬可选择性抑制阴茎海绵体组织中磷酸二酯酶Ｖ型（ＰＤＥ５）对环磷酸鸟苷（ＣＧＭＰ）的水解，提高ＣＧＭＰ的水平，而不影响环磷酸腺苷（ＣＡＭＰ），从而增加性刺激引起的ＮＯＳ／ＣＧＭＰ瀑布作用，使海绵体平滑肌松驰，达到治疗勃起功能障碍的目的。动物试验及临床试验表明：该药对各种原因所致的勃起功能障碍疗效满意，安全性好
Sildenafil selectively inhibits the hydrolysis of cyclic guanosine monophosphate (CGMP) by phosphodiesterase type V (PDE5) in the corpus cavernosal tissue and increases CGMP levels without affecting CAMP, thereby increasing the level of sexual stimulation Caused by the NOS / CGMP waterfall, so that spontaneous smooth muscle relaxation, to achieve the purpose of treatment of erectile dysfunction. Animal experiments and clinical trials show that: the drug for various causes of erectile dysfunction efficacy and safety