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机体在应激状态时，血浆β－内啡肽（β－EP）水平异常升高。而高浓度β－EP对红细胞免疫功能有抑制作用。红细胞可通过CD58、CD59、CH1、CR3与淋巴细胞、吞噬细胞上CD2、CR2、CR1t、CR3相互作用，参与免疫调控。本文检测了46例脑卒中伴医院感染患者及用β—EP阻断剂－纳洛酮对其中部分患者（23例）进行治疗后其血浆β－EP及外周血淋巴细胞计数的变化。结果表明：纳洛酮可阻断β—EP对RBC的抑制作用，提高细胞免疫功能，可用β－EP水平指导临床应用纳洛酮对脑卒中患者进行治疗。
Body in the stress state, the plasma β-endorphin (β-EP) levels were abnormally elevated. The high concentration of β-EP on erythrocyte immune function inhibition. Erythrocytes can participate in the immune regulation through the interaction of CD58, CD59, CH1, CR3 with lymphocytes, CD2, CR2, CR1, CR3 on phagocytes. In this paper, 46 cases of stroke patients with nosocomial infection and β-EP blockers - naloxone in some patients (23 cases) were treated, the changes of plasma β-EP and peripheral blood lymphocyte counts. The results showed that naloxone can block the inhibitory effect of β-EP on RBC and improve the cellular immune function. Naloxone can be used to guide the clinical treatment of patients with stroke by using β-EP level.