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作者于1985年1～11月对无乙型肝炎疫苗接种史的35名男性同性恋者作了研究。对所有受试者测定了抗人类免疫缺陷症病毒(HIV)抗体。在首次接种前采集的血清标本中,HBsAg、抗-HBs和抗-HBc均阴性。受试者分别于第0、1和6个月在臀部肌注20μg乙型肝炎疫苗。并分别于每次接种前和未次接种后3个月采血10ml,检测HBsAg、抗-HBc、抗-HBs和抗-HIV,并进行全血细胞计数。结果发现,18人的抗-HIV持续阴性,17人阳性。第3次接种后3个月,35名受试者的HBsAg和抗-HBc均为阴性。18名抗-HIV阴性者中仅1人未检出抗-HBs,而17名抗-HIV阳性者中有8人未检出抗-HBs,两者有显著差异(P<0.01)。抗-HIV阳性人群中,
From January to November 1985, the authors studied 35 male homosexuals without a history of hepatitis B vaccination. Anti-human immunodeficiency virus (HIV) antibodies were tested on all subjects. In the serum samples collected before the first vaccination, HBsAg, anti-HBs and anti-HBc were all negative. Subjects were intramuscularly injected with 20 μg hepatitis B vaccine at 0, 1, and 6 months respectively. Blood samples of 10 ml were collected 3 months prior to each inoculation and 3 months after the last inoculation to detect HBsAg, anti-HBc, anti-HBs and anti-HIV, and whole blood count was performed. The results showed that 18 anti-HIV persistent negative, 17 were positive. Three months after the third vaccination, 35 subjects had negative HBsAg and anti-HBc. Only one of the 18 anti-HIV negatives did not detect anti-HBs, whereas 8 out of 17 anti-HIV positives did not detect anti-HBs, a significant difference between the two (P <0.01). Among anti-HIV positives,