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目的 观察枢复宁预防硬膜外吗啡持续性术后镇痛引起恶心、呕吐的效果。方法 择期下腹部手术 6 0例 ,随机分为 3组 ,对照组 :吗啡 6mg +0 0 2mol·L-1布比卡因 2 0ml+生理盐水稀释至 6 0ml,持续镇痛 3天 ;氟哌利多组 :对照组配方中加入氟哌利多 5mg ;枢复宁组 :同对照组配方 ,分别于切皮及术毕静注枢复宁 4mg。观察术后镇痛 72h内恶心呕吐发生次数、镇痛效果以及药物副作用。结果 3组镇痛效果均较满意 ,氟哌利多组及枢复宁组术后恶心呕吐发生率均低于对照组 (P <0 0 5 )。结论 枢复宁对硬膜外吗啡术后持续镇痛引起的恶心呕吐有一定预防作用。
Objective To observe the effect of shufuning on prevention of nausea and vomiting caused by epidural morphine continuous postoperative analgesia. Methods Sixty patients undergoing elective lower abdominal surgery were randomly divided into 3 groups: control group: morphine 6 mg +0 0 2 mol·L-1 bupivacaine 2.0 ml + normal saline diluted to 60 ml, continuous analgesia for 3 days; droperidol Group: In the control group, droperidol 5 mg was added, and Shufuning group: in the same group as the control group. The number of nausea and vomiting, analgesic effect and side effects of drugs were observed within 72 hours after analgesia. Results The analgesic effects of the three groups were all satisfactory. The incidence of postoperative nausea and vomiting was lower in the droperidol group and the Shufuning group than in the control group (P < 0.05). Conclusion Shufuning has a preventive effect on nausea and vomiting caused by continuous analgesia after epidural morphine surgery.