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Objective To discuss mechanism of BH3 domain counterpart BH3I-2’ inducing colorectal cancer cell apoptosis.Methods Detected inhibition ratio and apoptosis of colorectal cancer cells HCT-116,which were treated by BH3I-2’,with microplate reader and flow cytometry.Results Inhibition ratio of colorectal cancer cells,which were treated by BH3I-2’,could reach about 50%.Ratio of viable apoptotic cell decreased and that of non-viable apoptotic cell increased as time went.Conclusions BH3I-2’ can induce colorectal cancer cell apoptosis.
Objective To discuss mechanism of BH3 domain counterpart BH3I-2 ’inducing colorectal cancer cell apoptosis. Methods Detected inhibition ratio and apoptosis of colorectal cancer cells HCT-116, which were treated by BH3I-2’ with microplate reader and flow cytometry. Results Inhibition ratio of colorectal cancer cells, which were treated by BH3I-2 ’, could reach about 50% .Ratio of viable apoptotic cell decreased and that of non-viable apoptotic cell increased as time went. Conclusions BH3I-2’ can induce colorectal cancer cell apoptosis.