目的：观察伊曲康唑胶囊联合2％酮康唑乳膏治疗足癣的近期临床疗效。方法：将94例足癣患者随机分为治疗组（口服伊曲康唑胶囊200 mg 每天1次，联合外用2％酮康唑乳膏每天2次）；对照组（单纯外用2％酮康唑乳膏每天2次）；两组各47例，用药疗程均为4周。观察两组患者用药后2周、4周及停药后2周的临床疗效和真菌学疗效及不良反应。结果：用药后2周治疗组和对照组总有效率分别为25．5％、17．0％，真菌清除率分别为25．5％、17．0％，两组比较差异无统计学意义（P＞0．05）；用药后4周治疗组和对照组总有效率分别为61．7％、40．4％，真菌清除率分别为68．1％、44．7％，两组比较差异有统计学意义（P＜0．05）；停药后2周治疗组和对照组总有效率分别为80．9、55．3％，真菌清除率分别为89．4％、59．6％，两组比较差异有统计学意义（P＜0．05）。两组患者用药后均无严重不良反应发生。结论：口服伊曲康唑胶囊联合外用2％酮康唑乳膏比单纯外用2％酮康唑乳膏治疗足癣近期临床疗效及真菌学疗效好，且副作用少，是临床治疗足癣疗效较好的方法之一。“,”Objective :To observe the efficacy of oral Itraconazole Capsules combined with external use 2% ketoconazole cream treating tinea pedis . Methods :94 patients with tinea pedis ,were randomly divided into treatment group and control group .Treatment group oral Itraconazole Capsules combined with external use 2% ketoconazole cream treating 47 patients with tinea pedis ,the total course of 4 weeks .Control group external use 2%ketoconazole cream treating 47 patients with tinea pedis ,the total course of 4 weeks .Observe two groups of patients with drug use 2 weeks、4 weeks and after discontinuation 2 weeks of clinical curative effect and mycology curative effect and adverse reactions .Results:Two groups of patients with drug use 2 weeks the effective rate were 25 .5% and 17 .0% respectively ,the fungus eradication rate were 34 .0% and 23 .4% respectively .There was no statistically significant difference comparing the two groups (P﹥0 .05) .Two groups of patients with drug use 4 weeks the effective rate were 61 . 7% and 40 .4% respectively ,the fungus eradication rate were 72 .3% and 46 .8% respectively .Comparative differences between the two groups have statistical significance (P<0 .05) .Two groups patients after discontinuation 2 weeks of the effective rate were 80 .9% and 55 .3% respectively ,the fun-gus eradication rate were 91 .5% and 61 .7% respectively .Comparative differences between the two groups have statistical significance (P<0 .05) .Two groups of patients with no serious adverse reaction after taking this medicine .Conclusion :Oral Itraconazole Capsules combined with external use 2%ketoconazole cream in the treatment of tinea pedis clinical curative effect and mycology curative effect is good ,Side effects are less .