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目的:研究西黄丸对荷瘤动物生存率和生存时间的影响。方法:采用2种荷瘤小鼠模型(肝癌H22、艾氏腹水瘤EAC),测定西黄丸其对荷瘤小鼠生存时间和生命延长率的影响。结果:西黄丸治疗各组小鼠生存状态良好,一般情况明显好于环磷酰胺组(化疗组)。同时,西黄丸在2.16g/kg剂量下,可明显延长荷瘤小鼠的生存时间(P<0.05),生命延长率可达30%以上。结论:西黄丸具有明确的抑瘤作用,可明显延长动物的生存时间,提高荷瘤动物的生存率,改善荷瘤动物的生存质量。
Objective: To study the effect of Xihuang Pill on the survival rate and survival time of tumor-bearing animals. Methods: Two kinds of tumor-bearing mouse models (H22, Ehrlich Ascites tumor EAC) were used to determine the effect of Xihuangwan on the survival time and the life extension rate of tumor-bearing mice. Results: Xihuang Pill showed good survival in all groups and the general situation was better than cyclophosphamide group (chemotherapy group). At the same time, Xihuang Wan at 2.16g / kg dose can significantly prolong the survival time of tumor-bearing mice (P <0.05), the life extension rate can reach more than 30%. Conclusion: XWG has a definite anti-tumor effect, which can significantly prolong the survival time of animals, improve the survival rate of tumor-bearing animals and improve the quality of life of tumor-bearing animals.