本方法是以(R)-3-羟基丁酸甲酯为初始原料,合成β-内酰胺(简写4-AA)的一条路线,它的优点是:其初始原料(R)-3-羟基丁酸乙酯是通过生物发酵生产的具有天然手性的P3hb通过高温高压裂解得来的。去除了以往纯化学合成手性拆分的麻烦,大大缩短了合成路线,而且此路线成本较低,有利于工业化。 This method is based on (R) -3-hydroxybutyrate as a starting material, synthesis of β-lactam (abbreviation 4-AA) of a route, its advantage is that: its initial raw material (R) Ethyl acetate is a naturally occurring chiral P3hb produced by biofermentation by pyrolysis at high temperature. Eliminate the trouble of pure chemical synthesis of chiral resolution, greatly shortening the synthesis route, and the lower cost of this route is conducive to industrialization.