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母乳喂养婴儿常见生理性腹泻,为探索母乳与生理性腹泻的关系,我们应用放射免疫分析法测定了320例产后4个月内健康母乳前列腺素E_2(PGE_2)含量,其均值为0.623±0.417μmol/L,腹泻组143例母乳PGE_2为0.823±0.409μmol/L;非腹泻组177例母乳PGE_2含量为0.375±0。219μmol/L,两者相比P<0.001。提示母乳PGE_2含量过高可能是婴儿生理性腹泻的重要原因。母乳PGE_2含量个体差异明显(0.046～2.823μmol/L),婴儿腹泻次数与母乳PGE_2含量呈正相关(r=0.75,P<0.01)。本文对102例母乳PGE_2含量高婴儿又有明显生理性腹泻者用随机分组法进行治疗观察,治疗组52例哺乳妇女口服消炎痛25mg每日2次,7～10天为1疗程,治疗前母乳PGE_2含量为0.950±0.449μmol/L,治疗后母乳PGE_2为0.409±0.173μmol/L,两者相比P<0.001,有高度显著性差异,同时见婴儿腹泻治愈46例,好转4例,总有效率96.15％。治疗中婴儿无任何副作用;哺乳妇女2例轻微副作用在停药后迅速消失。而安慰剂组50例用药后母乳PGE_2含量及婴儿腹泻均无改变。
In order to explore the relationship between breastfeeding and physiological diarrhea in breastfeeding infants, the content of prostaglandin E_2 (PGE_2) in 320 breastfeeding pregnant women was determined by radioimmunoassay, the average value was 0.623 ± 0.417μmol / L, 143 cases of breast milk PGE_2 of diarrhea group was 0.823 ± 0.409μmol / L; 177 cases of non-diarrhea group PGE 2 content of 0.375 ± 0.219μmol / L, P <0.001. Tip breast milk PGE 2 levels may be an important reason for infant physiological diarrhea. The PGE_2 content in breast milk was significantly different (0.046 ~ 2.823μmol / L), and the number of infantile diarrhea was positively correlated with PGE_2 in breast milk (r = 0.75, P <0.01). In this paper, 102 cases of breast milk PGE 2 high infants with significant physiological diarrhea randomized to observe the treatment group 52 cases of lactating women oral indomethacin 25 mg twice daily 7 to 10 days for a course of treatment before treatment of breast milk PGE_2 content of 0.950 ± 0.449μmol / L, breast milk PGE_2 after treatment was 0.409 ± 0.173μmol / L, both compared with P <0.001, there was a highly significant difference, while see 46 cases of infant diarrhea, improved in 4 cases, there are always Efficiency 96.15%. The treatment of infants without any side effects; lactating women 2 cases of minor side effects disappear rapidly after withdrawal. The placebo group of 50 patients with breast milk PGE 2 content and infant diarrhea no change.