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目的研究α-硫辛酸治疗2型糖尿病合并颈动脉硬化的临床效果。方法将64例2型糖尿病合并颈动脉硬化的患者随机分为对照组和治疗组。对照组30例,治疗组34例,分别给予维生素C和α-硫辛酸静脉滴注,均治疗14d。检测两组患者治疗前后的血糖、血脂、高敏C反应蛋白(hs-CRP)、内皮素(ET-1)及一氧化氮(NO)水平。结果与治疗前[hs-CRP(:4.4±2.5)mg/L、ET-1:(58.8±16.0)mg/L、NO(:44.8±17.6)μmol/L]比较,治疗组治疗后hs-CRP、ET-1水平均下降[分别为(2.3±1.4)、(41.5±9.4)mg/L],NO水平([54.6±17.9)μmol/L]升高,差异均有统计学意义(P<0.05,P<0.01)。对照组治疗前后hs-CRP、ET-1、NO水平的差异均无统计学意义(P>0.05)。结论α-硫辛酸可以改善血管内皮功能,抑制炎症反应,对2型糖尿病合并颈动脉硬化的患者有一定的治疗作用。
Objective To study the clinical effect of α-lipoic acid in the treatment of type 2 diabetes mellitus with carotid atherosclerosis. Methods 64 patients with type 2 diabetes with carotid atherosclerosis were randomly divided into control group and treatment group. The control group of 30 patients, 34 patients in the treatment group were given intravenous vitamin C and α-lipoic acid, were treated for 14 days. Blood glucose, blood lipids, high-sensitivity C-reactive protein (hs-CRP), endothelin (ET-1) and nitric oxide (NO) levels were measured before and after treatment in both groups. Results Compared with those before treatment [hs-CRP (4.4 ± 2.5) mg / L, ET-1: (58.8 ± 16.0) mg / L, NO (44.8 ± 17.6) μmol / L] (P <0.05). The level of NO, CRP and ET-1 were significantly decreased (P <0.05, P <0.01) <0.05, P <0.01). The levels of hs-CRP, ET-1 and NO in the control group before and after treatment showed no significant difference (P> 0.05). Conclusion α-lipoic acid can improve vascular endothelial function, inhibit the inflammatory response and have some therapeutic effects on type 2 diabetes patients with carotid atherosclerosis.