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本文观察了107例IgA 肾病患者肾内纤维连接蛋白(Fn)的分布,发现在肾小球内其分布范围与系膜区增生程度平行,在新月体、严重系膜增生、节段及部分全球硬化区内Fn 大量增多。如将全部病例分为单纯系膜区分布组(M 组)和毛细血管袢分布组(B 组),发现B 组患者在病变程度、新月体形成、IgG、IgA、C_3及FRA 在肾内的沉积均明显重于M 组;电镜下可见B 组病人肾小球基底膜受损明显。与M 组比较B 组患者高血压及非选择性蛋白尿发生率较高、蛋白尿重、血肌酐清除率下降程度明显、并与病变活动密切相关。因此,作者认为Fn 在肾小球毛细血管袢上的增加可反映毛细血管壁受损及病变活动的程度。
This article observed 107 cases of IgA nephropathy in patients with renal fibronectin (Fn) distribution and found that its distribution within the glomerular and mesangial area parallel to the degree of proliferation in the crescent, severe mesangial proliferation, segmental and part Global Fz a substantial increase in Fn. If all cases were divided into simple mesangial area distribution group (M group) and capillaries distribution group (B group), found that patients in group B lesions, crescent formation, IgG, IgA, C_3 and FRA in the kidney Of the deposition were significantly heavier than the M group; electron microscopy showed the group B patients with glomerular basement membrane damage significantly. Patients in group B had higher incidence of hypertension and non-selective proteinuria, proteinuria and serum creatinine clearance than those in group M, and were significantly associated with pathological changes. Therefore, the authors suggest that the increase in Fn in glomerular capillaries may reflect the extent of capillary wall damage and lesion activity.