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作为药物代谢酶、药物转运载体、药物受体和离子通道编码的基因,其多态现象可影响到个体产生药物不良反应的危险性或改变治疗个体的药物功效。对个体产生药物不良反应的危险因子研究得最成功的是单个基因位点上的等位基因突变,包括许多药物代谢酶的编码基因。这些药物代谢酶的基因多态现象产生了许多药物慢代谢或超快代谢的表现型。总之,上述表现型在人群中已组成固定的比例。未来的药物基因组技术能有效地分析这些危险因
As a gene of drug metabolism enzyme, drug transporter, drug receptor and ion channel, the polymorphism may affect the risk of adverse drug reactions in the individual or change the drug efficacy of the treated individual. The most successful study of risk factors for adverse drug reactions in individuals has been the study of allelic mutations at a single locus, including many genes encoding drug-metabolizing enzymes. The genetic polymorphisms of these drug-metabolizing enzymes produce many phenotypes of slow metabolism or ultra-fast metabolism of drugs. In summary, these phenotypes have established a fixed proportion in the population. Future pharmacogenomics techniques can effectively analyze these risk factors