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目的 探讨苯妥英 (PhenytoinPHT)治疗成人癫痫的合理用药。 方法 选择苯妥英钠单药治疗的原发性全身强直一阵挛性发作 (PGTCS)患者 6 7例 ,根据临床效果 ,结合实测血药浓度 ,调整剂量 ,至少观察半年判断临床疗效。结果 不同的个体、不同的病程、不同的病情 ,PHT的有效剂量 (10 0～ 4 5 0mg/d)和血药浓度 (2 .77～ 4 8.5 2 μg/ml)有很大的差异。结论 PHT治疗癫痫应根据个体选择最佳剂量 ,确定有效血药浓度。
Objective To investigate the rational use of Phenytoin PHT in the treatment of adult epilepsy. Methods Sixty-seven patients with primary tonic-clonic seizure (PGTCS) treated with phenytoin monotherapy were enrolled in this study. According to the clinical effect and combined with the measured blood concentration, the dose was adjusted to observe the clinical efficacy at least for six months. The results of different individuals, different duration, different conditions, the effective dose of PHT (100 ~ 450mg / d) and plasma concentrations (2.77 ~ 4 8.52 ug / ml) are very different. Conclusion PHT treatment of epilepsy should be based on individual selection of the best dose to determine the effective plasma concentration.