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对大鼠经气管内注入青石棉纤维，在染尘后９０、１８０、２７０、３６０和５４０天动态观察血和肺中超氧化物歧化酶（ＳＯＤ）、脂质过氧化物（ＬＰＯ）及ＳＯＤ／ＬＰＯ比值的变化。结果表明，青石棉可诱发大鼠血和肺组织中自由基反应增强，ＳＯＤ活性降低，脂质过氧化反应增高，ＬＰＯ含量升高，抗氧化能力降低，ＳＯＤ／ＬＰＯ比值降低，体内抗氧化和脂质过氧化平衡失调。
The asbestos fibers were injected intratracheally into rats and the activities of superoxide dismutase (SOD), lipoperoxidase (LPO) and superoxide dismutase (SOD) in blood and lungs were observed at 90, 180, 270, LPO ratio changes. The results showed that crocidolite could induce the increase of free radicals in blood and lung tissue, decrease the activity of SOD, increase the lipid peroxidation, increase the content of LPO, decrease the antioxidant capacity, decrease the ratio of SOD / LPO, Lipid peroxidation imbalance.