论文部分内容阅读
目的探讨连续性血液净化(CBP)治疗脓毒症并多脏器功能不全(MODS)患者的效果。方法 50例脓毒症并MODS患者,通过连续性静脉-静脉血液过滤(CVVH)的方式,对患者进行CBP治疗。观察比较两组治疗前后的序贯器官衰竭估计(SOFA)、多器官功能障碍综合征(MODS)、急性生理与慢性健康(APACHEII)评分、细胞间黏附分子(ICAM-1)、血乳酸、外周血生化指标及血管活性药物用量情况。结果患者治疗后SOFA、MODS、APACHEⅡ评分、乳酸、ICAM-1情况均优于治疗前,差异具有统计学意义(P<0.05)。治疗后外周血各项生化指标均优于治疗前,差异具有统计学意义(P<0.05)。治疗后血管活性药物用量少于治疗前,差异具有统计学意义(P<0.05)。结论 CBP治疗MODS患者疗效明显,能提高脓毒症患者生存率,稳定患者生命体征,减少对血管活性药物的依赖,值得临床推广。
Objective To investigate the effect of continuous blood purification (CBP) on patients with sepsis and multiple organ dysfunction (MODS). Methods 50 patients with sepsis and MODS were treated with CBP by continuous venovenous hemofiltration (CVVH). The levels of SOFA, MODS, APACHEII, ICAM-1, blood lactate and peripheral blood were measured before and after treatment in two groups. Blood biochemical indicators and the amount of vasoactive drugs. Results After treatment, SOFA, MODS, APACHEⅡscore, lactic acid and ICAM-1 were all better than those before treatment, the difference was statistically significant (P <0.05). After treatment, the biochemical indexes in peripheral blood were better than before treatment, the difference was statistically significant (P <0.05). The amount of vasoactive drugs after treatment was less than before treatment, the difference was statistically significant (P <0.05). Conclusion CBP treatment of MODS patients with significant effect, can improve the survival rate of patients with sepsis, stable patient vital signs and reduce the dependence on vasoactive drugs, is worth clinical promotion.